Former Australian captain Meg Lanning has been dismissed cheaply by a teenage spinner in her debut match for London Spirit in England's Hundred competition.

Lanning made 12 from 12 balls before falling caught-and-bowled to 16-year-old Tilly Corteen-Coleman.

Heather Knight produced a batting masterclass as the Spirit shocked the reigning Hundred champions Southern Brave with a six-wicket win in a thrilling contest at Utilita Bowl on Wednesday.

Chasing 152 for victory, the England captain made an unbeaten 65 from 31 balls to steer her team to victory with three deliveries to spare, inflicting only a second-ever home defeat on Brave.

The hosts looked on course for victory after Danni Wyatt had struck 59 from 35 balls, in the process surpassing Sophia Dunkley to become The Hundred's all-time leading run-scorer.

Fellow England opener Maia Bouchier made 35 for the home side before she was run out after a mix-up with Wyatt, ending a rapid opening stand of 57.

Wyatt took the attack to Spirit, registering her seventh half-century in The Hundred before she edged behind off Erin Burns.

Captain Georgia Adams (21) and Chloe Tryon (20) propelled Brave to 6-151 and Spirit made a slow start in reply.

Knight said beating the Brave was "really tough to do so I'm really chuffed with how we went today".

"We knew it was a good wicket. They probably got 10 or 15 too many, we dropped a few catches.

In the men's competition, a superb display from Southern Brave's seamers and a ruthless run-chase orchestrated by James Vince ensured the men's competition's inaugural winners prevailed against London Spirit.

The Spirit scored 3-138 from their 16.4 overs with the Brave chasing down the total with 11 balls to spare.

Invited to field first, Brave's attack dominated the opening stages, with left-arm spinner James Coles inducing a miscued lofted drive from Adam Rossington for the first wicket.

Craig Overton took the catch and then took centre stage, picking up the next three wickets - all to outfield catches - to rip through the Spirit's middle order.

Jofra Archer bowled fast in his first appearance in the Hundred, while Tymal Mills and Chris Jordan provided ferocious back-up.

Spirit skipper Dan Lawrence struck 38 off 30 balls, with Liam Dawson offering spirited lone resistance at the death with 45 off just 19 deliveries.

In reply, Vince stroked four boundaries in his first five balls to set Brave on their way and in partnership with Daniel Hughes, the pair put on 95 for the first wicket.

Hughes nicked Ravi Bopara to Rossington behind the stumps for 45 but Vince went to his fifth half-century in the competition's history and despite lofting a catch to long-off with the score on 117, the final 22 runs were negotiated with little undue fuss as the Brave eased home.