Saquon Barkley has scored three touchdowns in his debut for Philadelphia, leading the Eagles past Green Bay 34-29 in the first NFL game in South America.

Some Philadelphia players had expressed reluctance earlier this week about travelling to Brazil, which cost them the opportunity to play their season opener in front of a friendly crowd at Lincoln Financial Field. The crowd at NeoQuimica Arena on Friday night instead was balanced among Packers fans, Eagles fans and spectators who just cheered any positive development.

Green Bay quarterback Jordan Love limped off the field with assistance after getting injured with six seconds left. Back-up Malik Willis was sacked by Zack Baun on the final play of the game, preventing him from launching a Hail Mary from the Eagles' 47.

Barkley rushed for 109 yards and scored on an 18-yard catch and runs of 11 and two yards. Barkley spent six seasons with the New York Giants before Philadelphia signed him to a three-year, $US37.75 million ($A56.6 million) deal with $US26 million ($A39 million) guaranteed.

He became the first player to score three touchdowns in his Eagles debut since Terrell Owens in 2004.

Jalen Hurts was 20 of 34 for 278 yards with two touchdowns and two interceptions for Philly, while A.J. Brown caught five passes for 119 yards, including a 67-yard touchdown.

Green Bay's Jayden Reed scored on a 33-yard jet sweep and a 70-yard reception, which was the longest touchdown completion of Love's career.

Reed became the first player to have a touchdown catch of 30-plus yards and a touchdown run of 30-plus yards in a season opener since Hall of Famer Jim Brown of the Cleveland Browns against Washington in 1963.

Love went 17 of 34 for 260 yards with two touchdowns and an interception.

Barkley's third touchdown put the Eagles ahead 31-26 with 4:26 left in the third quarter. Reed Blankenship set up that score with an interception that gave Philadelphia the ball at Green Bay's 25.

The Eagles still led 31-26 when Jaire Alexander intercepted Hurts in the end zone early in the fourth quarter. Green Bay drove into the red zone but settled for a 26-yard field goal by rookie Brayden Narveson.

Philadelphia then controlled possession until Jake Elliott kicked a 21-yard field goal with 27 seconds left.